Abstract
The layer-by-layer (LbL) adsorption of anionic polyelectrolytes (PE) and tobramycin sulfate (TbS) multilayers on zinc oxide core particles followed by the controlled core-removal process leads to the formation of ultrathin capsules, which gradually convert to biaqueous vesicles and emulsionlike systems depending on the hydrophilicity/hydrophobicity of the PE backbone, PE/TbS ratio, and Zn2+ concentration. The unique characteristics of the PE/TbS multilayer capsules result because of the formation of PE/TbS/H2O biphasic liquid systems unlike the other LbL capsular systems that form stiff PE coacervates when mixed together in water. This paper investigates the PE/TbS ultrathin capsule to biaqueous vesicle transition and its physicochemical properties.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adsorption
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Biocompatible Materials / chemistry*
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Capsules / chemistry
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Cell Membrane / metabolism
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Delayed-Action Preparations
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Dose-Response Relationship, Drug
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Drug Carriers
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Drug Compounding / methods
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Electrolytes / chemistry
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Microscopy, Confocal
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Microscopy, Electron, Transmission
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Models, Chemical
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Molecular Weight
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Particle Size
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Polymers / chemistry
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Polystyrenes / chemistry
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Scattering, Radiation
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Spectrum Analysis, Raman
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Surface Properties
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Time Factors
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Tobramycin / chemistry*
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Water / chemistry
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X-Rays
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Zinc / chemistry
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Zinc Oxide / chemistry*
Substances
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Biocompatible Materials
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Capsules
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Delayed-Action Preparations
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Drug Carriers
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Electrolytes
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Polymers
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Polystyrenes
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Water
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Zinc
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Zinc Oxide
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Tobramycin