Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin

M G Golubeva; M E Grigoreva; M P Smirnova

doi:10.1007/s10517-005-0434-8

Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin

Bull Exp Biol Med. 2005 Aug;140(2):162-4. doi: 10.1007/s10517-005-0434-8.

Authors

M G Golubeva¹, M E Grigoreva, M P Smirnova

Affiliation

¹ Department of Human and Animals Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. mgolubeva46@mail.ru

PMID: 16282990
DOI: 10.1007/s10517-005-0434-8

Abstract

We studied the effect of vasopressin analogue desglycinamide-arginine-vasopressin on changes in platelet hemostasis produced by intragastric administration of Ticlid or clopidogrel (inhibitors of ADP-induced platelet aggregation). Intranasal administration of the peptide under conditions of hemorrhagic diathesis produced a hemostatic effect and normalized some parameters of blood coagulation.

MeSH terms

Adenosine Diphosphate / metabolism*
Animals
Arginine Vasopressin / analogs & derivatives*
Arginine Vasopressin / pharmacology
Blood Platelets / drug effects
Clopidogrel
Hemostasis / drug effects
Hemostatics / pharmacology
Platelet Aggregation / drug effects*
Platelet Aggregation Inhibitors / pharmacology
Platelet Function Tests
Rats
Ticlopidine / analogs & derivatives
Ticlopidine / pharmacology
Vasopressins / chemistry*

Substances

Hemostatics
Platelet Aggregation Inhibitors
Vasopressins
Arginine Vasopressin
argipressin, des-GlyNH2(9)-
Adenosine Diphosphate
Clopidogrel
Ticlopidine