The Georg Klingmüller Clinic is part of Mbarara University Teaching Hospital (MUST) in south-western Uganda. Established in 1999, this clinic cares for about 6,000 dermatological patients per year. We review the disease spectrum, available diagnostic tools, and therapeutic options in this clinic. In addition, the importance of dermatology for the fight against HIV/AIDS is discussed with respect to the socio-economic background of a sub-Saharan country. Co-operation with dermatology departments in Germany may not only help to diagnose skin diseases in Mbarara, but may also be valuable for the visiting dermatologist to manage the increasing numbers of patients with dark skin at home.