The influence of a dry extract from Bergenia crassifolia (Fritsch) on the specific immune response parameters was studied under extremal conditions of model immunodepressive states induced by immobilization stress or cyclophosphamide injections. The drug produced normalizing effect on the content of antibody-forming cells in the spleen of experimental mice under the conditions of humoral response stimulation by antigen and in both immunodepression models. The bergenia extract decreases expression of inflammatory processes under delayed hypersensitivity reaction conditions, by preventing the accumulation of T-lymphocytes in the inflammation focus and reducing the ability of cells to produce anti-inflammatory cytokines.