Hypoglycemic activity of a new carbohydrate isolated from the roots of Psacalium peltatum

Chem Pharm Bull (Tokyo). 2005 Nov;53(11):1408-10. doi: 10.1248/cpb.53.1408.

Abstract

A new ulopyranose isolated from aqueous extract of roots and rhizomas of Psacalium peltatum has been determined to have hypoglycemic activity at doses of 100 mg/kg, comparable to that of tolbutamide and insulin in alloxan diabetic mice. The skeletal structure of the new compound was established by spectral analysis.

MeSH terms

  • Acetylation
  • Animals
  • Asteraceae / chemistry*
  • Blood Glucose / chemistry
  • Carbohydrates / isolation & purification*
  • Carbohydrates / pharmacology*
  • Diabetes Mellitus, Experimental / blood
  • Diabetes Mellitus, Experimental / drug therapy
  • Hypoglycemic Agents / isolation & purification*
  • Hypoglycemic Agents / pharmacology*
  • Imino Pyranoses
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared

Substances

  • Blood Glucose
  • Carbohydrates
  • Hypoglycemic Agents
  • Imino Pyranoses
  • Plant Extracts
  • petalosa