Synthesis of the C6-C21 segment of amphidinolide E

James A Marshall; Gregory Schaaf; Andrew Nolting

doi:10.1021/ol0523493

Synthesis of the C6-C21 segment of amphidinolide E

Org Lett. 2005 Nov 10;7(23):5331-3. doi: 10.1021/ol0523493.

Authors

James A Marshall¹, Gregory Schaaf, Andrew Nolting

Affiliation

¹ Department of Chemistry, University of Virginia, P.O. Box 400319, Charlottesville, Virginia 22904, USA. jam5x@virginia.edu

PMID: 16268571
DOI: 10.1021/ol0523493

Abstract

[reaction: see text] A convergent approach to a C6-C21 segment of the polyketide amphidinolide E has been developed through combination of three subunits by allenylindium bromide-aldehyde addition and Suzuki sp2-sp3 coupling.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
Bridged Bicyclo Compounds, Heterocyclic / chemistry
Catalysis
Dinoflagellida / chemistry
Macrolides / chemical synthesis*
Macrolides / chemistry
Molecular Structure

Substances

Bridged Bicyclo Compounds, Heterocyclic
Macrolides
amphidinolide E

Grants and funding

CA090383/CA/NCI NIH HHS/United States