A novel azetidinyl gamma-lactam based peptide with a preference for beta-turn conformation

Org Biomol Chem. 2005 Nov 21;3(22):4050-2. doi: 10.1039/b511029g. Epub 2005 Oct 12.

Authors

Amit Basak¹, Subhash C Ghosh, Amit K Das, Valerio Bertolasi

Affiliation

¹ Bioorganic Chemistry Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, 721302, India.

PMID: 16267581
DOI: 10.1039/b511029g

Abstract

Novel azetidinyl gamma-lactam based peptides have been synthesized with only compound showing a preference for the beta-turn conformation.

MeSH terms

Azetidines / chemical synthesis*
Azetidines / chemistry
Hydrogen Bonding
Lactams / chemical synthesis*
Lactams / chemistry
Magnetic Resonance Spectroscopy
Peptides / chemical synthesis
Peptides / chemistry*
Protein Conformation
Pyrrolidinones / chemical synthesis
Pyrrolidinones / chemistry
Temperature

Substances

Azetidines
Lactams
Peptides
Pyrrolidinones