The temperature/pressure dependency of marine prokaryotes and fungi, in terms of their growth behaviour as well as their potential to produce new metabolites or enzymes, is evaluated. Advanced shake-flask cultivations and controlled bioreactor cultivations following the batch-type, fed-batch-type and/or continuous-type procedures are summarized. After a summary of the fermentation data available so far, values on maximal biomass, specific growth rates, and (sub)optimal production yields are presented. The application of mesophilic microbes, especially bioactive metabolites, to intensify bioprocess engineering studies, is the goal. Cold-active enzymes and thermostable enzymes are the targets of experiments with psychrophilic and hyperthermophilic enzymes. A special challenge to bioengineers is also provided by barophilic strains originating from depths of, say, nearly 11000 m, or from hydrothermal vents.