Prostaglandin F2alpha produced by inducible cyclooxygenase may contribute to the resolution of inflammation

Inflammopharmacology. 2005;12(5-6):473-6; discussion 477-80. doi: 10.1163/156856005774382616.

Abstract

Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2alpha concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2alpha produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Cyclooxygenase 2 / metabolism*
  • Cyclooxygenase Inhibitors / pharmacology
  • Cyclooxygenase Inhibitors / toxicity
  • Dinoprost / biosynthesis*
  • Inflammation / chemically induced
  • Inflammation / drug therapy
  • Inflammation / metabolism*
  • Nitrobenzenes / pharmacology
  • Nitrobenzenes / toxicity
  • Pleurisy / chemically induced
  • Pleurisy / drug therapy
  • Pleurisy / metabolism
  • Prostaglandins F, Synthetic / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Prostaglandin / antagonists & inhibitors
  • Sulfonamides / pharmacology
  • Sulfonamides / toxicity

Substances

  • Cyclooxygenase Inhibitors
  • Nitrobenzenes
  • Prostaglandins F, Synthetic
  • Receptors, Prostaglandin
  • Sulfonamides
  • prostaglandin F2alpha receptor
  • N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
  • fluprostenol
  • Dinoprost
  • Cyclooxygenase 2