High prevalence of glycopeptide resistance genes vanB, vanD, and vanG not associated with enterococci in human fecal flora

Antimicrob Agents Chemother. 2005 Nov;49(11):4784-6. doi: 10.1128/AAC.49.11.4784-4786.2005.

Abstract

The presence of Enterococcus-associated vancomycin resistance genes vanA, vanB, vanD, vanE, and vanG in rectal swabs was investigated in two hospitals using PCR. All vanA genes detected were associated with vancomycin-resistant enterococci (VRE), whereas VRE-associated vanB genes were detected in only one hospital (4.7%). However, in both hospitals, high prevalences of vanB (6.2 and 2.3%), vanD (43.8 and 26.7%), and vanG (10.5 and 6.9%) genes not associated with enterococci were found.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics*
  • Drug Resistance, Microbial / genetics*
  • Enterococcus / drug effects*
  • Enterococcus / genetics
  • Feces / microbiology*
  • Humans
  • Peptide Synthases / genetics*
  • Polymerase Chain Reaction
  • Vancomycin Resistance / genetics*

Substances

  • Bacterial Proteins
  • VanB protein, Enterococcus
  • VanG protein, Enterococcus faecalis
  • Peptide Synthases
  • VanD protein, Enterococcus faecium