Abstract
The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-kappaB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.
MeSH terms
-
Animals
-
Apoptosis*
-
Cell Membrane / metabolism*
-
Cell Survival
-
Humans
-
Interleukin-1 / metabolism
-
MAP Kinase Signaling System
-
NF-kappa B / metabolism
-
Protein Binding
-
Protein Structure, Tertiary
-
Receptors, Cell Surface / metabolism*
-
Signal Transduction
-
Structure-Activity Relationship
-
TNF Receptor-Associated Factor 1 / physiology
-
TNF Receptor-Associated Factor 2 / physiology
-
TNF Receptor-Associated Factor 3 / physiology
-
TNF Receptor-Associated Factor 4
-
TNF Receptor-Associated Factor 5 / physiology
-
TNF Receptor-Associated Factor 6 / physiology
-
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism
-
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / physiology*
Substances
-
Interleukin-1
-
NF-kappa B
-
Receptors, Cell Surface
-
TNF Receptor-Associated Factor 1
-
TNF Receptor-Associated Factor 2
-
TNF Receptor-Associated Factor 3
-
TNF Receptor-Associated Factor 4
-
TNF Receptor-Associated Factor 5
-
TNF Receptor-Associated Factor 6
-
TRAF4 protein, human
-
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins