Direct experimental observation of the effect of the base pairing on the oxidation potential of Guanine

Tonino Caruso; Maurizio Carotenuto; Ermanno Vasca; Andrea Peluso

doi:10.1021/ja055130s

Direct experimental observation of the effect of the base pairing on the oxidation potential of Guanine

J Am Chem Soc. 2005 Nov 2;127(43):15040-1. doi: 10.1021/ja055130s.

Authors

Tonino Caruso¹, Maurizio Carotenuto, Ermanno Vasca, Andrea Peluso

Affiliation

¹ Dipartimento di Chimica, Università di Salerno, via Salvador Allende, 43 Baronissi, Italy 84081.

PMID: 16248639
DOI: 10.1021/ja055130s

Abstract

The effect of complementary base pairing on the oxidation potential of a guanosine derivative has been determined by cyclic and differential pulse voltammetry in CHCl3. The formation of the Watson-Crick H-bonded complex lowers the oxidation potential of the free molecule by 0.34 V, which compares well with the value obtained by DFT/B3LYP/6-311++g** computations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Pairing*
Electrochemistry / methods
Guanine / analogs & derivatives*
Oligonucleotides / chemistry*
Oxidation-Reduction

Substances

Oligonucleotides
Guanine