Natural phosphate doped with KI in HMDS: a mild and efficient reagent for alkylation and glycosylation of nucleobases

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):1093-5. doi: 10.1081/ncn-200059179.

Abstract

Several D-ribonucleosides are prepared from 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranoside and trimethylsilylated nucleobases under mild conditions by using natural phosphate doped with KI as catalyst.

MeSH terms

  • Alkylation
  • Catalysis
  • Chromatography
  • Glycosides / chemistry
  • Glycosylation
  • Hydrocarbons / chemistry
  • Indicators and Reagents / chemistry
  • Methane / analogs & derivatives
  • Methane / chemistry
  • Models, Chemical
  • Molecular Biology / methods*
  • Nucleosides / chemistry
  • Phosphates / chemistry*
  • Potassium Iodide / chemistry

Substances

  • Glycosides
  • Hydrocarbons
  • Indicators and Reagents
  • Nucleosides
  • Phosphates
  • Potassium Iodide
  • carbene
  • Methane