Novel strategy for single nucleotide polymorphism (SNP) genotyping by heteroduplex analysis: specific stabilization of TT mismatch base pair by mercury (II) cation and CC mismatch base pair by silver (I) cation

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):915-7. doi: 10.1081/ncn-200059274.

Authors

Hidetaka Torigoe¹, Kouji Kawahashi, Ayako Takamori, Akira Ono

Affiliation

¹ Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo, Japan. htorigoe@ch.kagu.tus.ac.jp

PMID: 16248061
DOI: 10.1081/ncn-200059274

No abstract available

MeSH terms

Base Pair Mismatch*
Binding Sites
Cations*
Cell Line, Tumor
Chemistry, Pharmaceutical / methods*
Drug Design
Genetic Techniques*
Genotype
Heteroduplex Analysis / methods*
Humans
Inhibitory Concentration 50
Mercury
Models, Chemical
Nucleic Acid Heteroduplexes* / chemistry
Polymorphism, Single Nucleotide*
Silver / chemistry
Temperature
Ultraviolet Rays

Substances

Cations
Nucleic Acid Heteroduplexes
Silver
Mercury