Gold DNA-conjugates: ion specific self-assembly of gold nanoparticles via the dG-quartet

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):843-6. doi: 10.1081/ncn-200060322.

Abstract

The Oxytricha telomere DNA hairpin 5'-d(G4T4G4) immobilized on 13 nm gold nanoparticles forms a supramolecular assembly via dGC-quartets, as determined by the color change and by SEM. The aggregation is ion-dependent and selective for sodium ions. K+ is less efficient while Li+ and Cs+ do not drive the aggregation. This work is the first effort exploring the use of secondary structures of DNA (quadruplexes) for producing self-assemblies of gold nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / chemistry
  • Gold / chemistry
  • Guanine / chemistry
  • Ions
  • Macromolecular Substances
  • Microscopy, Electron, Scanning
  • Molecular Conformation
  • Molecular Sequence Data
  • Nanostructures* / chemistry
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Nucleic Acid Heteroduplexes
  • Potassium / chemistry
  • Sodium / chemistry
  • Telomere / ultrastructure
  • Ultraviolet Rays

Substances

  • Ions
  • Macromolecular Substances
  • Nucleic Acid Heteroduplexes
  • Guanine
  • Gold
  • DNA
  • Sodium
  • isoguanine
  • Potassium