Abstract
The Oxytricha telomere DNA hairpin 5'-d(G4T4G4) immobilized on 13 nm gold nanoparticles forms a supramolecular assembly via dGC-quartets, as determined by the color change and by SEM. The aggregation is ion-dependent and selective for sodium ions. K+ is less efficient while Li+ and Cs+ do not drive the aggregation. This work is the first effort exploring the use of secondary structures of DNA (quadruplexes) for producing self-assemblies of gold nanoparticles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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DNA / chemistry
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Gold / chemistry
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Guanine / chemistry
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Ions
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Macromolecular Substances
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Microscopy, Electron, Scanning
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Molecular Conformation
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Molecular Sequence Data
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Nanostructures* / chemistry
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Nucleic Acid Conformation
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Nucleic Acid Denaturation
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Nucleic Acid Heteroduplexes
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Potassium / chemistry
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Sodium / chemistry
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Telomere / ultrastructure
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Ultraviolet Rays
Substances
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Ions
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Macromolecular Substances
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Nucleic Acid Heteroduplexes
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Guanine
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Gold
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DNA
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Sodium
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isoguanine
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Potassium