Abstract
Coupling suitable sugars (D- or L-ribofuranose, 2' or 3-deoxysugar, branched sugars) with 2-aminoimidazo[1,2-a]-s-triazin-4-one was carried out using the different reaction conditions: 1) condensation in the presence of sodium hydride; or 2) condensation using Vorbrüggen's methods. The 5-aza- 7-deazaguanine nucleoside analogues obtained were evaluated in cell culture experiments for the inhibition of the replication of a number of RNA viruses, including BVDV, YFV, and WNV.
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Chemistry, Pharmaceutical / methods
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Drug Design
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Flavivirus / metabolism*
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Flavivirus Infections / drug therapy*
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Guanine / analogs & derivatives*
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Guanine / chemical synthesis
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Guanosine / analogs & derivatives*
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Guanosine / chemical synthesis
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Humans
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Models, Chemical
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Nucleosides / chemistry
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Pyrimidine Nucleosides / chemistry
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Ribonucleosides / chemistry
Substances
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Antiviral Agents
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Nucleosides
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Pyrimidine Nucleosides
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Ribonucleosides
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Guanosine
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Guanine
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7-deazaguanine