Abstract
Phthalimido-alkyl alcohol solid supports were rapidly prepared from solid supported phthalic anhydride and amino alcohol condensation induced by microwaves. These supports were used to synthesize 13-aminoalkyl oligodeoxynucleotides allowing a two step deprotection necessary to avoid aminolink alkylation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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DNA / chemistry
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Microwaves*
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Models, Chemical
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Molecular Biology / methods*
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Oligonucleotides / chemical synthesis*
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Oligonucleotides / chemistry
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Oligonucleotides / radiation effects
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Time Factors
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Ultraviolet Rays