Homo and heterodimers of ddI, d4T and AZT: influence of (5'-5') thiolcabonate-carbamate linkage on anti-HIV activity

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):523-5. doi: 10.1081/ncn-200061793.

Abstract

New homo and heterodimers of ddI, d4T and AZT with (5-5) thiolcarbonate-carbamate linkages have been prepared with the aim of testing them against wild type and NNRTI resistant HIV mutants. The prepared dimers showed a low activity in comparison to the parent drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology
  • Carbamates / chemistry*
  • Didanosine / chemistry*
  • Dimerization
  • HIV / genetics
  • HIV / metabolism*
  • HIV Infections / drug therapy
  • Models, Chemical
  • Molecular Conformation
  • Mutation
  • Stavudine / chemistry*
  • Sulfhydryl Compounds / chemistry*
  • Zidovudine / chemistry*

Substances

  • Anti-HIV Agents
  • Antiviral Agents
  • Carbamates
  • Sulfhydryl Compounds
  • Zidovudine
  • Stavudine
  • Didanosine