Abstract
New homo and heterodimers of ddI, d4T and AZT with (5-5) thiolcarbonate-carbamate linkages have been prepared with the aim of testing them against wild type and NNRTI resistant HIV mutants. The prepared dimers showed a low activity in comparison to the parent drug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / pharmacology*
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology
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Carbamates / chemistry*
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Didanosine / chemistry*
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Dimerization
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HIV / genetics
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HIV / metabolism*
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HIV Infections / drug therapy
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Models, Chemical
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Molecular Conformation
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Mutation
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Stavudine / chemistry*
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Sulfhydryl Compounds / chemistry*
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Zidovudine / chemistry*
Substances
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Anti-HIV Agents
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Antiviral Agents
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Carbamates
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Sulfhydryl Compounds
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Zidovudine
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Stavudine
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Didanosine