Treatment delay and the risk of prolonged status epilepticus

Neurology. 2005 Oct 25;65(8):1316-8. doi: 10.1212/01.wnl.0000180959.31355.92.

Abstract

Factors contributing to the duration of a single convulsive seizure > 5 minutes were analyzed in 157 children. The medically treated episodes were compared with seizure episodes resolving without treatment (n = 27). Major differences were in age (p = 0.016) and etiology (p = 0.003), and the association between treatment delay and response became significant after 30 minutes when this was analyzed as a single variable (p = 0.003) in Cox regression analysis.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Rectal
  • Anticonvulsants / administration & dosage*
  • Anticonvulsants / adverse effects
  • Benzodiazepines / administration & dosage
  • Benzodiazepines / adverse effects
  • Child, Preschool
  • Clinical Protocols / standards*
  • Disease Progression
  • Early Diagnosis
  • Epilepsy / drug therapy*
  • Epilepsy / etiology
  • Epilepsy / physiopathology
  • Female
  • Humans
  • Infusion Pumps
  • Male
  • Phenobarbital / administration & dosage
  • Phenobarbital / adverse effects
  • Phenytoin / administration & dosage
  • Phenytoin / adverse effects
  • Phenytoin / analogs & derivatives
  • Retrospective Studies
  • Secondary Prevention
  • Status Epilepticus / physiopathology
  • Status Epilepticus / prevention & control*
  • Thiopental / administration & dosage
  • Thiopental / adverse effects
  • Time Factors
  • Treatment Outcome

Substances

  • Anticonvulsants
  • Benzodiazepines
  • Phenytoin
  • fosphenytoin
  • Thiopental
  • Phenobarbital