Aims: The aim of this study was to evaluate the efficacy of mitomycin C in reducing postoperative adhesions following strabismus surgery.
Methods: This study was a prospective, single-center, interventional case series. We randomized 14 patients with restrictive strabismus to the mitomycin C group (7 patients) or to the control group (7 patients). We used mitomycin C intraoperatively for 5 min at a concentration of 0.2 mg/mL in the mitomycin group after adhesion release. We compared postoperative results using the forced duction test.
Results: Compared to the control group, the mitomycin C group exhibited a better range of passive duction at all postoperative follow-up times; however, mitomycin C did not completely eliminate the problem of postoperative adhesions. Patients receiving mitomycin C did not report any complications during this study.
Conclusions: The intraoperative application of mitomycin C is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.