Sporeamicin A, a new macrolide antibiotic. I. Taxonomy, fermentation, isolation and characterization

J Antibiot (Tokyo). 1992 May;45(5):599-606. doi: 10.7164/antibiotics.45.599.

Abstract

Sporeamicin A, a novel antibiotic, was isolated from the culture filtrate of an actinomycete. The producing organism, strain L53-18, was taxonomically assigned as a species of the genus Saccaropolyspora. The antibiotic was extracted with chloroform and was then purified by crystallization. It was obtained as colorless prisms from ethanolic solutions. Sporeamicin A exhibited a strong UV absorption peak at 276 nm. The molecular formula of sporeamicin A was determined to be C37H63NO12.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Erythromycin / analogs & derivatives*
  • Erythromycin / chemistry
  • Erythromycin / isolation & purification
  • Erythromycin / pharmacology
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Saccharopolyspora / chemistry*
  • Saccharopolyspora / classification

Substances

  • Anti-Bacterial Agents
  • sporeamicin A
  • Erythromycin