Low yield for extended reading of patch tests with topical corticosteroids

Dermatitis. 2005 Sep;16(3):124-6.

Abstract

Background: On the basis of reports that up to 30% of patch test reactions are missed if an extended reading is not performed, we required that patients who were being patch tested with the corticosteroid series return for a reading at least 1 week after placement of the allergens.

Objective: To report our institutional experience with extended readings (day 7 or beyond) of patch test reactions to the corticosteroid series.

Methods: We retrospectively reviewed patch test reactions to corticosteroids since extended readings were implemented (April 2001 to June 2004).

Results: A total of 135 patients were patch tested with 1,656 corticosteroid allergens. On day 5, five patients had five positive patch test reactions; by the time of the extended reading, no new reactions had developed in these patients. Of the patients with no reactions on day 5, two had a positive result at the extended reading: each had a relevant reaction to budesonide 0.1%, one on day 7 and the other on day 9.

Conclusions: Only 2 reactions (to 1,656 corticosteroids) became apparent at the extended reading. Extended readings were of limited value in our experience.

MeSH terms

  • Administration, Topical
  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects*
  • Dermatitis, Allergic Contact / diagnosis*
  • Dermatitis, Allergic Contact / etiology
  • Drug Eruptions / diagnosis*
  • Drug Eruptions / etiology
  • Humans
  • Patch Tests / methods*
  • Predictive Value of Tests
  • Retrospective Studies
  • Time Factors

Substances

  • Adrenal Cortex Hormones