Asymptotic time dependence in the fractal pharmacokinetics of a two-compartment model

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Sep;72(3 Pt 1):031903. doi: 10.1103/PhysRevE.72.031903. Epub 2005 Sep 9.

Abstract

We further investigate, both analytically and numerically, the properties of the fractal two-compartment model introduced by Fuite [J. Fuite, R. Marsh, and J. Tuszynski, Phys. Rev. E 66, 021904 (2002)]. Specifically, we look at the effects of the fractal exponent of the elimination rate coefficient on the long-time behavior of the pharmacokinetic clearance tail. For small exponent values, the tail exhibits exponential behavior, while for larger values, there is a transition to a power law. The theory is applied to seven data sets simulating drugs taken from the pharmacological literature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Simulation
  • Fractals*
  • Kinetics
  • Metabolic Clearance Rate
  • Models, Biological*
  • Pharmacokinetics*
  • Time Factors