Abstract
Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / pharmacology
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Angiogenesis Inhibitors / pharmacology
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Animals
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Aorta / drug effects
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Cell Line, Tumor
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Drug Screening Assays, Antitumor / methods
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Humans
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Inhibitory Concentration 50
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Mice
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Models, Chemical
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Phenanthrolines / chemistry*
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Phenanthrolines / pharmacology
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Quinolizines / chemistry*
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Quinolizines / pharmacology
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Rats
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Stereoisomerism
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Stilbenes / pharmacology
Substances
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Alkaloids
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Angiogenesis Inhibitors
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Phenanthrolines
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Quinolizines
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Stilbenes
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julandine
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cryptopleurine
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fosbretabulin