Abstract
[reaction: see text] We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.
MeSH terms
-
Amination
-
Anti-Arrhythmia Agents / chemical synthesis
-
Anti-Arrhythmia Agents / chemistry
-
Antipsychotic Agents / chemical synthesis
-
Antipsychotic Agents / chemistry
-
Aripiprazole
-
Catalysis
-
Methylation
-
Molecular Structure
-
Phosphites / chemistry*
-
Phosphites / metabolism
-
Piperazines / chemical synthesis*
-
Piperazines / chemistry
-
Quinolones / chemical synthesis*
-
Quinolones / chemistry
-
Rhodium / chemistry*
-
Rhodium / metabolism
-
Stereoisomerism
-
Sulfonamides / chemical synthesis*
-
Sulfonamides / chemistry
Substances
-
Anti-Arrhythmia Agents
-
Antipsychotic Agents
-
Phosphites
-
Piperazines
-
Quinolones
-
Sulfonamides
-
ibutilide
-
Aripiprazole
-
Rhodium