[Current concepts of the physiopathology of coronary beta-adrenergic receptors, and their clinical applications]

Emanuele Barbato; William Wijns; Bernard De Bruyne; Giuseppe Mascia; Federico Piscione

[Current concepts of the physiopathology of coronary beta-adrenergic receptors, and their clinical applications]

Recenti Prog Med. 2005 Sep;96(9):411-5.

[Article in Italian]

Authors

Emanuele Barbato¹, William Wijns, Bernard De Bruyne, Giuseppe Mascia, Federico Piscione

Affiliation

¹ Cattedra di Cardiologia, Università Federico II, Napoli. barba22@hotmail.com

PMID: 16229320

Abstract

Beta-adrenergic vasodilation plays a key role in the regulation of coronary blood flow, in particular during sympathetic nervous system activation. Beta1-adrenergic receptors are mostly represented in epicardial coronary vessel, while beta2 receptors are located in microvasculature. Coronary atherosclerosis is associated with a significant impairment of beta-adrenergic receptor response. This might contribute to precipitate myocardial ischemia.

Publication types

English Abstract
Review

MeSH terms

Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Agonists / therapeutic use*
Coronary Artery Disease / drug therapy
Coronary Artery Disease / metabolism*
Coronary Circulation*
Humans
Receptors, Adrenergic, beta / metabolism*
Receptors, Adrenergic, beta-1 / metabolism
Receptors, Adrenergic, beta-2 / metabolism

Substances

Adrenergic beta-Agonists
Receptors, Adrenergic, beta
Receptors, Adrenergic, beta-1
Receptors, Adrenergic, beta-2