Purpose: To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy.
Design: Observational cases report.
Methods: Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3.
Results: Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening.
Conclusions: In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a foveolar cystoid space different from macular edema.