Time course of cell proliferation in rat liver in the early postnatal ontogeny and role of epidermal growth factor in organization of proliferative regimen

V B Zakharov; S N Smirnov; S G Mamontov; E T Zakharova

doi:10.1007/s10517-005-0361-8

Time course of cell proliferation in rat liver in the early postnatal ontogeny and role of epidermal growth factor in organization of proliferative regimen

Bull Exp Biol Med. 2005 May;139(5):622-5. doi: 10.1007/s10517-005-0361-8.

[Article in English, Russian]

Authors

V B Zakharov¹, S N Smirnov, S G Mamontov, E T Zakharova

Affiliation

¹ Russian State Medical University, Moscow. zakharov4@yandex.ru

PMID: 16224565
DOI: 10.1007/s10517-005-0361-8

Abstract

Circadian rhythm of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on days 3, 7, and 12 of life. Age-associated differences in the rhythmic parameters of these characteristics were detected. Epidermal growth factor plays an important role in the formation of cell proliferation rhythm in the early postnatal ontogeny and in the formation of proliferative hepatocyte pool.

MeSH terms

Animals
Cell Proliferation*
Circadian Rhythm / physiology
Epidermal Growth Factor / metabolism*
Hepatocytes / physiology*
Liver / growth & development*
Rats
Time Factors

Substances

Epidermal Growth Factor