[Amisulpride in Huntington's disease]

Psychiatr Prax. 2005 Oct;32(7):363-6. doi: 10.1055/s-2003-815024.
[Article in German]

Abstract

Objectives: Amisulpride is a substituted benzamide derivative with atypical antipsychotic properties and low side effects.

Method: We report four cases of patients with clinically and genetically established Huntington's disease and signs of psychosis who were treated with Amisulpride.

Results: Two patients developed extrapyramidal side effects due to the treatment. The antipsychotic therapy of all patients was effective.

Discussion: Due to degeneration of striatal neurons patients suffering from Huntington's disease react early with development of extrapyramidal side effects after therapy with amisulpride.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amisulpride
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Delusions / diagnosis
  • Delusions / drug therapy
  • Delusions / genetics
  • Delusions / psychology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Huntington Disease / diagnosis
  • Huntington Disease / drug therapy*
  • Huntington Disease / genetics
  • Huntington Disease / psychology
  • Male
  • Middle Aged
  • Neurologic Examination / drug effects
  • Neuropsychological Tests
  • Parkinson Disease, Secondary / chemically induced
  • Parkinson Disease, Secondary / diagnosis
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / drug therapy
  • Psychotic Disorders / genetics
  • Psychotic Disorders / psychology
  • Sulpiride / adverse effects
  • Sulpiride / analogs & derivatives*
  • Sulpiride / therapeutic use
  • Treatment Outcome

Substances

  • Antipsychotic Agents
  • Sulpiride
  • Amisulpride