In vitro photo-release of a TRPV1 agonist

Bioorg Med Chem Lett. 2006 Jan 1;16(1):208-12. doi: 10.1016/j.bmcl.2005.09.018. Epub 2005 Oct 5.

Abstract

Intracellular photolysis of a novel 'caged' capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism
  • Capsaicin / analogs & derivatives*
  • Cells, Cultured
  • Diterpenes / pharmacology
  • Electrophysiology
  • Humans
  • Ion Channels / metabolism
  • Light
  • Models, Chemical
  • Neurons / metabolism
  • Protein Binding
  • Rats
  • Structure-Activity Relationship
  • TRPV Cation Channels / antagonists & inhibitors*

Substances

  • Diterpenes
  • Ion Channels
  • TRPV Cation Channels
  • TRPV1 protein, human
  • Trpv1 protein, rat
  • resiniferatoxin
  • Capsaicin
  • Calcium