Abstract
Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Aorta, Thoracic / physiology
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Benzyl Compounds / chemistry*
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Benzyl Compounds / isolation & purification
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Benzyl Compounds / pharmacology*
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Calcium / pharmacology
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Dose-Response Relationship, Drug
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Furans / chemistry*
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Furans / isolation & purification
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Furans / pharmacology*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Male
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Microbial Sensitivity Tests
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Molecular Structure
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Onygenales / chemistry*
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Potassium / pharmacology
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Rats
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Rats, Wistar
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Spectrometry, Mass, Electrospray Ionization
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Vasodilator Agents / chemistry*
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Vasodilator Agents / pharmacology*
Substances
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4-benzyl-3-phenyl-5H-furan-2-one
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Benzyl Compounds
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Furans
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Vasodilator Agents
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Potassium
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Calcium