4-benzyl-3-phenyl-5H-furan-2-one, a vasodilator isolated from Malbranchea filamentosa IFM 41300

Phytochemistry. 2005 Dec;66(23):2776-9. doi: 10.1016/j.phytochem.2005.08.014. Epub 2005 Oct 5.

Abstract

Screening of Malbranchea filamentosa IFM 41300 for bioactive compounds led to the identification of 4-benzyl-3-phenyl-5H-furan-2-one (1) as a vasodilator and erythroglaucin (2). The structure of 1 was established on the basis of spectroscopic and chemical investigations. Compound 1 inhibited Ca2+-induced vasocintraction in aortic rings pretreated with high K+ (60mM) or norepinephrine. Finally, compound 1 did not exhibit activity against human pathogenic microorganisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aorta, Thoracic / drug effects
  • Aorta, Thoracic / physiology
  • Benzyl Compounds / chemistry*
  • Benzyl Compounds / isolation & purification
  • Benzyl Compounds / pharmacology*
  • Calcium / pharmacology
  • Dose-Response Relationship, Drug
  • Furans / chemistry*
  • Furans / isolation & purification
  • Furans / pharmacology*
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Male
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Onygenales / chemistry*
  • Potassium / pharmacology
  • Rats
  • Rats, Wistar
  • Spectrometry, Mass, Electrospray Ionization
  • Vasodilator Agents / chemistry*
  • Vasodilator Agents / pharmacology*

Substances

  • 4-benzyl-3-phenyl-5H-furan-2-one
  • Benzyl Compounds
  • Furans
  • Vasodilator Agents
  • Potassium
  • Calcium