Abstract
The maintenance of adequate amounts of bile acids in the liver, biliary tract, and intestine requires a finely tuned control of their synthesis. A paper in this issue of Cell Metabolism by Inagaki et al. (2005) indicates that sensing of the levels of bile acids in the intestine may trigger the secretion of a hormone which regulates bile acid production in the liver.
MeSH terms
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Bile Acids and Salts / biosynthesis*
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Bile Acids and Salts / metabolism
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Cholesterol 7-alpha-Hydroxylase / biosynthesis
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Enterohepatic Circulation
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Fibroblast Growth Factors / metabolism*
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Humans
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Intestinal Mucosa / metabolism*
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Liver / enzymology
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Liver / metabolism*
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Receptor, Fibroblast Growth Factor, Type 4 / metabolism
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Signal Transduction
Substances
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Bile Acids and Salts
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fibroblast growth factor 15, mouse
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Fibroblast Growth Factors
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Cholesterol 7-alpha-Hydroxylase
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Cyp7a1 protein, mouse
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Receptor, Fibroblast Growth Factor, Type 4