Abstract
[reaction: see text] The arylation of ethyl acetoacetate, ethyl benzoyl acetate, and diethyl malonate under the catalysis of CuI/L-proline in DMSO proceeds smoothly at 40-50 degrees C in the presence of Cs2CO3 to provide the 2-aryl-1,3-dicarbonyl compounds in good yields. Both aryl iodides and aryl bromides are compatible with these reaction conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzene Derivatives / chemical synthesis*
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Benzene Derivatives / chemistry
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Catalysis
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Copper / chemistry*
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Hydrocarbons, Halogenated / chemistry*
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Iodides / chemistry*
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Methane / chemistry*
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Molecular Structure
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Proline / chemistry*
Substances
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Benzene Derivatives
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Hydrocarbons, Halogenated
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Iodides
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Copper
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cuprous iodide
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Proline
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Methane