Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease

Neurobiol Aging. 2006 Oct;27(10):1431-4. doi: 10.1016/j.neurobiolaging.2005.08.010. Epub 2005 Oct 3.

Abstract

We have initiated a systematic analysis of the role of cholesterol metabolizing genes as risk factors for Alzheimer's disease pathogenesis. As part of this analysis, we have assessed the NR1H2 gene on chromosome 19 and report here a modest association with the locus in sibpairs with late onset disease.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics
  • Apolipoproteins E / genetics*
  • Chromosome Aberrations
  • Chromosomes, Human, Pair 19 / genetics*
  • DNA Mutational Analysis / methods
  • Female
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing / methods
  • Genetic Variation / genetics
  • Heterozygote
  • Humans
  • Incidence
  • Liver X Receptors
  • Male
  • Middle Aged
  • Orphan Nuclear Receptors
  • Polymorphism, Genetic
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Retrospective Studies
  • Risk Assessment / methods*
  • Risk Factors
  • United States / epidemiology

Substances

  • Apolipoproteins E
  • Liver X Receptors
  • NR1H2 protein, human
  • Orphan Nuclear Receptors
  • Receptors, Cytoplasmic and Nuclear