Enantioselective construction of stereogenic quaternary centres via Rh-catalyzed asymmetric addition of alkenylboronic acids to alpha,beta-unsaturated pyridylsulfones

Pablo Mauleón; Juan C Carretero

doi:10.1039/b508142d

Enantioselective construction of stereogenic quaternary centres via Rh-catalyzed asymmetric addition of alkenylboronic acids to alpha,beta-unsaturated pyridylsulfones

Chem Commun (Camb). 2005 Oct 21:(39):4961-3. doi: 10.1039/b508142d. Epub 2005 Sep 8.

Authors

Pablo Mauleón¹, Juan C Carretero

Affiliation

¹ Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco 28049 Madrid, Spain.

PMID: 16205814
DOI: 10.1039/b508142d

Abstract

The highly enantioselective construction of all-carbon quaternary stereogenic centres via Rh-catalyzed Chiraphos-mediated conjugate addition of alkenylboronic acids to beta,beta-disubstituted alpha,beta-unsaturated 2-pyridylsulfones is described.