Abstract
An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)(4), a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Leucine / analogs & derivatives*
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Leucine / chemical synthesis
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Leucine / chemistry*
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Rhodium / chemistry*
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Stereoisomerism
Substances
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Organometallic Compounds
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dirhodium(II) tetrakis(N-phthaloyl-(S)-tert-leucinate)
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Rhodium
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Leucine