Practical synthesis of Dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate]

Chem Pharm Bull (Tokyo). 2005 Oct;53(10):1366-8. doi: 10.1248/cpb.53.1366.

Abstract

An efficient and reliable procedure for the preparation of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate], Rh2(S-PTTL)(4), a universally effective catalyst for a range of enantioselective carbene transformations, is described. The N-phthaloylation of (S)-tert-leucine by the method of Bose with essentially no racemization is a key to this process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Leucine / analogs & derivatives*
  • Leucine / chemical synthesis
  • Leucine / chemistry*
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Organometallic Compounds
  • dirhodium(II) tetrakis(N-phthaloyl-(S)-tert-leucinate)
  • Rhodium
  • Leucine