Deletion of the sigB gene in Bacillus cereus ATCC 14579 leads to hydrogen peroxide hyperresistance

Appl Environ Microbiol. 2005 Oct;71(10):6427-30. doi: 10.1128/AEM.71.10.6427-6430.2005.

Abstract

The sigB gene of Bacillus cereus ATCC 14579 encodes the alternative sigma factor sigma(B). Deletion of sigB in B. cereus leads to hyperresistance to hydrogen peroxide. The expression of katA, which encodes one of the catalases of B. cereus, is upregulated in the sigB deletion mutant, and this may contribute to the hydrogen peroxide-resistant phenotype.

MeSH terms

  • Bacillus cereus / drug effects*
  • Bacillus cereus / enzymology
  • Bacillus cereus / genetics
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Catalase / genetics
  • Catalase / metabolism
  • Culture Media
  • Drug Resistance, Bacterial*
  • Gene Deletion*
  • Gene Expression Regulation, Bacterial
  • Hydrogen Peroxide / pharmacology*
  • Sigma Factor / genetics*
  • Up-Regulation

Substances

  • Bacterial Proteins
  • Culture Media
  • SigB protein, Bacteria
  • Sigma Factor
  • Hydrogen Peroxide
  • Catalase
  • KATA protein, Bacillus subtilis