Many evidences have been established about reduction of cardiovascular event of long-acting calcium antagonists. It has been reported that long-acting calcium antagonists reduce cardiovascular risk more than other drugs, and calcium antagonists are important in Japan, where stroke is very popular and calcium antagonists are widely used. Calcium antagonists have not only strength and sharpness of reduction blood pressure (BP), but also improve morning hypertension and abnormal variation of BP through appropriate reduction of BP. Calcium antagonists might be used after due consideration home and ambulatory BP in addition to clinic BP.