Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%

Erin M Warshaw; Katherine R St Clair

doi:10.1016/j.jaad.2005.06.019

Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%

J Am Acad Dermatol. 2005 Oct;53(4):717-20. doi: 10.1016/j.jaad.2005.06.019.

Authors

Erin M Warshaw¹, Katherine R St Clair

Affiliation

¹ Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA. erin.warshaw@med.va.gov

PMID: 16198805
DOI: 10.1016/j.jaad.2005.06.019

Abstract

The objective of this 2-year, double-blind, placebo-controlled, randomized trial involving 48 participants was to determine if biweekly miconazole powder prevents onychomycosis recurrence. Intent-to-treat analysis found no significant differences in mycologic, clinical, or complete onychomycosis reinfection rates or time to reinfection. Limitations include small sample size and dosing regimen.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Antifungal Agents / therapeutic use*
Double-Blind Method
Female
Foot Dermatoses / drug therapy
Humans
Male
Miconazole / therapeutic use*
Middle Aged
Onychomycosis / prevention & control*
Pilot Projects
Recurrence

Substances

Antifungal Agents
Miconazole