The pressure dependence of the critical temperature T(c) and upper critical field H(c2)(T) has been measured up to 19 GPa in the layered superconducting material 2H-NbSe2. T(c)(P) has a maximum at 10.5 GPa, well above the pressure for the suppression of the charge density wave (CDW) order. Using an effective two-band model to fit H(c2)(T), we obtain the pressure dependence of the anisotropy in the electron-phonon coupling and Fermi velocities, which reveals the peculiar interplay between CDW order, Fermi surface complexity, and superconductivity in this system.