Abstract
The newly discovered molecular features of well-differentiated thyroid carcinomas derived from follicular cells are reviewed, within the frame of the 2004 WHO classification of thyroid tumours, under the following headings: "Follicular carcinoma", "Papillary carcinoma", "Follicular variant of papillary carcinoma" and "Hürthle cell tumours". A particular emphasis is put on the meaning of PAX8-PPARgamma rearrangements, RAS and BRAF mutations, and deletions and mutations of mitochondrial genes and of nuclear genes encoding for mitochondrial enzymes, for thyroid tumorigenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenoma, Oxyphilic / genetics*
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Adenoma, Oxyphilic / pathology
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Carcinoma, Papillary, Follicular / genetics*
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Carcinoma, Papillary, Follicular / pathology
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Gene Rearrangement*
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Genes, ras
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Humans
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Mutation
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PAX8 Transcription Factor
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PPAR gamma / genetics
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Paired Box Transcription Factors / genetics
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Proto-Oncogene Proteins B-raf / genetics
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Thyroid Neoplasms / classification
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Thyroid Neoplasms / genetics*
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Thyroid Neoplasms / pathology
Substances
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PAX8 Transcription Factor
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PAX8 protein, human
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PPAR gamma
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Paired Box Transcription Factors
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BRAF protein, human
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Proto-Oncogene Proteins B-raf