Abstract
Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution*
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Anti-Infective Agents / pharmacology*
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Ciprofloxacin / pharmacology*
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Drug Resistance, Bacterial / genetics
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Escherichia coli / drug effects
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Proteins / genetics*
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Microbial Sensitivity Tests
Substances
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Anti-Infective Agents
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Escherichia coli Proteins
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Ciprofloxacin