Abstract
Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amphotericin B / pharmacology*
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Animals
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Antifungal Agents / pharmacology*
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Cell Size / drug effects*
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Cryptococcosis / drug therapy*
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Cryptococcus neoformans / drug effects*
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Cryptococcus neoformans / genetics
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Female
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Mice
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Mice, Inbred C57BL
Substances
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Antifungal Agents
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Amphotericin B