Thrombophilia and fetal germinal matrix-intraventricular hemorrhage: does it matter?

Ultrasound Obstet Gynecol. 2005 Oct;26(5):574-6. doi: 10.1002/uog.2586.

Abstract

Germinal matrix-intraventricular hemorrhage (GMH-IVH) in the fetus is very rare and the role of thrombophilia in its pathogenesis is unclear. We report on the prenatal diagnosis by magnetic resonance imaging of GMH-IVH in a 24-week fetus. The newborn presented posthemorrhagic ventriculomegaly and was found to be heterozygous for two thrombophilic patterns, factor V Leiden and methylenetetrahydrofolate reductase mutation. The combination of this hypercoagulable state and prenatal GMH-IVH is discussed together with the opportunity of testing these infants for thrombophilia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / genetics
  • Cerebral Ventricles / abnormalities*
  • Factor V
  • Female
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Magnetic Resonance Imaging / methods*
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Polymorphism, Genetic
  • Pregnancy
  • Prenatal Diagnosis / methods*
  • Thrombophilia / diagnosis*
  • Thrombophilia / genetics

Substances

  • factor V Leiden
  • Factor V
  • Methylenetetrahydrofolate Reductase (NADPH2)