Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli

Catherine E McNamara; Lesley Larsen; Nigel B Perry; Jacquie L Harper; Michael V Berridge; Elizabeth W Chia; Michelle Kelly; Victoria L Webb

doi:10.1021/np050171n

Anti-inflammatory sesquiterpene-quinones from the New Zealand sponge Dysidea cf. cristagalli

J Nat Prod. 2005 Sep;68(9):1431-3. doi: 10.1021/np050171n.

Authors

Catherine E McNamara¹, Lesley Larsen, Nigel B Perry, Jacquie L Harper, Michael V Berridge, Elizabeth W Chia, Michelle Kelly, Victoria L Webb

Affiliation

¹ TerraMarine Pharmaceuticals, New Zealand Institute for Crop & Food Research Ltd, Chemistry Department, University of Otago, PO Box 56, Dunedin, New Zealand.

PMID: 16180831
DOI: 10.1021/np050171n

Abstract

The inhibition of superoxide production by human neutrophils has been used to screen New Zealand's unique biota for anti-inflammatory natural products. Bioactivity-directed isolation on an extract of the sponge Dysidea cf. cristagalli led to a new sesquiterpene-quinone (4) with anti-inflammatory activity, plus acetylated hydroquinone (3). These compounds inhibited superoxide production in vitro with IC50's of 3 microM (3) and 11 microM (4).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Dysidea / chemistry*
Humans
Inhibitory Concentration 50
Molecular Structure
Neutrophils / drug effects
New Zealand
Quinones / chemistry
Quinones / isolation & purification*
Quinones / pharmacology
Sesquiterpenes / chemistry
Sesquiterpenes / isolation & purification*
Sesquiterpenes / pharmacology
Superoxides / metabolism

Substances

20-O-acetyl-21-hydroxy-ent-isozonarol
21-hydroxy-ent-isozonarone
Anti-Inflammatory Agents, Non-Steroidal
Quinones
Sesquiterpenes
Superoxides