Echinamines A and B, first aminated hydroxynaphthazarins from the sea urchin Scaphechinus mirabilis

Natalia P Mischenko; Sergey A Fedoreyev; Nataly D Pokhilo; Victor Ph Anufriev; Vladimir A Denisenko; Valery P Glazunov

doi:10.1021/np049585r

Echinamines A and B, first aminated hydroxynaphthazarins from the sea urchin Scaphechinus mirabilis

J Nat Prod. 2005 Sep;68(9):1390-3. doi: 10.1021/np049585r.

Authors

Natalia P Mischenko¹, Sergey A Fedoreyev, Nataly D Pokhilo, Victor Ph Anufriev, Vladimir A Denisenko, Valery P Glazunov

Affiliation

¹ Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, 159, Prospect 100 let Vladivostoku, Vladivostok 690022, Russian Federation. misch@piboc.dvo.ru

PMID: 16180820
DOI: 10.1021/np049585r

Abstract

Two new spinochromes, echinamines A (1) and B (2), were isolated from the sea urchin Scaphechinus mirabilis. Compounds 1 and 2 represent the first examples of natural polyhydroxynaphthazarins with a primary amine group. The structures of 1 and 2 were established by analysis of spectroscopic data and synthesis of their dimethyl ethers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biphenyl Compounds
Japan
Molecular Structure
Naphthoquinones / chemistry
Naphthoquinones / isolation & purification*
Nuclear Magnetic Resonance, Biomolecular
Picrates / pharmacology
Sea Urchins / chemistry*

Substances

Biphenyl Compounds
Naphthoquinones
Picrates
echinamine A
echinamine B
1,1-diphenyl-2-picrylhydrazyl