Abstract
Human IgM+ IgD+ CD27+ B cells have mutated Ig genes and harbor a splenic marginal zone (MZ) phenotype. In this issue, the group of R. Küppers has studied the expression of the enzyme activation-induced cytidine deaminase (AID) in human spleen samples by immunocytochemistry and failed to detect a significant AID-expressing subset in the MZ region. The consequences on the possible origin of these cells are discussed.
MeSH terms
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Animals
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B-Lymphocyte Subsets / cytology*
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B-Lymphocyte Subsets / immunology*
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Cell Lineage / immunology*
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Cytidine Deaminase
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Cytosine Deaminase / immunology
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Cytosine Deaminase / metabolism
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Humans
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Immunoglobulins / genetics*
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Mutation
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Spleen / cytology*
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Spleen / immunology
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Tumor Necrosis Factor Receptor Superfamily, Member 7 / immunology
Substances
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Immunoglobulins
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Tumor Necrosis Factor Receptor Superfamily, Member 7
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AICDA (activation-induced cytidine deaminase)
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Cytosine Deaminase
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Cytidine Deaminase