Abstract
[reactions: see text] Compound 1, 2-(4-phenoxyphenylsulfonylmethyl)thiirane, is a selective inhibitor of gelatinases, which is showing high promise in studies of animal models for cancer metastasis and stroke. The (R)-1 and (S)-1 enantiomers of compound 1 were each synthesized in this study and were shown to be equally active in inhibition of gelatinases.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Binding Sites
-
Kinetics
-
Matrix Metalloproteinase 2 / chemistry
-
Matrix Metalloproteinase 2 / metabolism
-
Matrix Metalloproteinase 9 / chemistry
-
Matrix Metalloproteinase 9 / metabolism
-
Matrix Metalloproteinase Inhibitors*
-
Methylation
-
Models, Molecular
-
Molecular Structure
-
Protease Inhibitors / chemical synthesis*
-
Protease Inhibitors / chemistry
-
Protease Inhibitors / pharmacology*
-
Stereoisomerism
-
Structure-Activity Relationship
-
Sulfides / chemical synthesis
-
Sulfides / chemistry*
-
Sulfides / pharmacology*
Substances
-
Matrix Metalloproteinase Inhibitors
-
Protease Inhibitors
-
Sulfides
-
ethylene sulfide
-
Matrix Metalloproteinase 2
-
Matrix Metalloproteinase 9