[Expression of urotensin II and G-protein coupled receptor 14 mRNA in human pheochromocytoma tissues]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Aug;27(4):457-60.
[Article in Chinese]

Abstract

Objective: To investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.

Methods: Total RNA from normal adrenal and pheochromocytoma tissues was extracted. The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.

Results: There was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla. The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05). The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).

Conclusion: U II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex / metabolism
  • Adrenal Gland Neoplasms / metabolism*
  • Adrenal Medulla / metabolism
  • Humans
  • Pheochromocytoma / metabolism*
  • RNA, Messenger / biosynthesis
  • RNA, Messenger / genetics
  • Receptors, G-Protein-Coupled / biosynthesis*
  • Receptors, G-Protein-Coupled / genetics
  • Urotensins / biosynthesis*
  • Urotensins / genetics

Substances

  • RNA, Messenger
  • Receptors, G-Protein-Coupled
  • UTS2R protein, human
  • Urotensins
  • urotensin II