Abstract
Enantio- and diastereoselective syntheses of a substituted oxazolidinone, isoxazoline and pyrazoline as beta-lactam surrogates are described. The substituted heterocycles were designed to incorporate side chains closely resembling those found in the beta-lactam cholesterol absorption inhibitor ezetimibe (1). Additionally, the in vitro inhibitory efficacy of the novel compounds as cholesterol absorption inhibitors is reported using a brush border membrane vesicle assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticholesteremic Agents / chemical synthesis*
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Anticholesteremic Agents / pharmacology
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Azetidines / pharmacology
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Ezetimibe
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Heterocyclic Compounds / chemistry*
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Isoxazoles / chemistry
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Molecular Structure
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Oxazolidinones / chemistry
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Pyrazoles / chemistry
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Stereoisomerism
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beta-Lactams / chemistry
Substances
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Anticholesteremic Agents
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Azetidines
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Heterocyclic Compounds
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Isoxazoles
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Oxazolidinones
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Pyrazoles
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beta-Lactams
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Ezetimibe